STRINGSTRING
arc protein (Nocardioides sp. JS614) - STRING interaction network
"arc" - Vesicle-fusing ATPase in Nocardioides sp. JS614
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arcVesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a ’key in a lock’ to induce gate opening and therefore regulate proteolysis (584 aa)    
Predicted Functional Partners:
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (283 aa)
 
 
  0.980
prcA
20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (255 aa)
 
 
  0.971
pafA
Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (453 aa)
 
     
  0.941
Noca_2643
Hypothetical protein (502 aa)
 
     
  0.881
Noca_2638
tRNA (adenine-58-N(1)-) methyltransferase (316 aa)
 
        0.762
Noca_2637
Peptidase M50 (378 aa)
 
        0.755
Noca_0179
Hypothetical protein (192 aa)
   
          0.750
Noca_2636
Hypothetical protein (299 aa)
 
        0.749
Noca_0002
DNA polymerase III subunit beta; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (408 aa)
   
  0.741
Noca_2565
ABC transporter-like protein (627 aa)
 
  0.735
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
Server load: low (10%) [HD]