node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noca_0179 | Noca_2643 | Noca_0179 | Noca_2643 | KEGG: tfu:Tfu_0071 hypothetical protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | 0.644 |
Noca_0179 | arc | Noca_0179 | Noca_2639 | KEGG: tfu:Tfu_0071 hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.793 |
Noca_0179 | pafA | Noca_0179 | Noca_2648 | KEGG: tfu:Tfu_0071 hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.719 |
Noca_0179 | prcA | Noca_0179 | Noca_2646 | KEGG: tfu:Tfu_0071 hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.986 |
Noca_0179 | prcB | Noca_0179 | Noca_2645 | KEGG: tfu:Tfu_0071 hypothetical protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.951 |
Noca_0179 | pup | Noca_0179 | Noca_2644 | KEGG: tfu:Tfu_0071 hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.660 |
Noca_1310 | Noca_3101 | Noca_1310 | Noca_3101 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.978 |
Noca_1310 | arc | Noca_1310 | Noca_2639 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.987 |
Noca_1310 | prcA | Noca_1310 | Noca_2646 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.939 |
Noca_1310 | prcB | Noca_1310 | Noca_2645 | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.939 |
Noca_2643 | Noca_0179 | Noca_2643 | Noca_0179 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | KEGG: tfu:Tfu_0071 hypothetical protein. | 0.644 |
Noca_2643 | arc | Noca_2643 | Noca_2639 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.897 |
Noca_2643 | pafA | Noca_2643 | Noca_2648 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.589 |
Noca_2643 | prcA | Noca_2643 | Noca_2646 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.968 |
Noca_2643 | prcB | Noca_2643 | Noca_2645 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.964 |
Noca_2643 | pup | Noca_2643 | Noca_2644 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: sma:SAV6678 proteasome component. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.970 |
Noca_3101 | Noca_1310 | Noca_3101 | Noca_1310 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein. | 0.978 |
Noca_3101 | arc | Noca_3101 | Noca_2639 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.983 |
Noca_3101 | prcA | Noca_3101 | Noca_2646 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.940 |
Noca_3101 | prcB | Noca_3101 | Noca_2645 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome endopeptidase complex, beta component, Threonine peptidase, MEROPS family T01B; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.940 |