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ligA protein (Nocardioides sp. JS614) - STRING interaction network
"ligA" - DNA ligase, NAD-dependent in Nocardioides sp. JS614
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5’-phosphoryl and 3’-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (752 aa)    
Predicted Functional Partners:
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (509 aa)
     
 
  0.843
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (706 aa)
 
 
  0.755
Noca_3006
DNA polymerase I (889 aa)
 
 
  0.749
leuS
leucyl-tRNA synthetase (848 aa)
 
 
  0.715
Noca_3593
ATP-dependent DNA helicase PcrA (797 aa)
 
   
  0.709
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (360 aa)
   
   
  0.689
Noca_1947
DNA primase (932 aa)
 
   
  0.679
Noca_3442
EmrB/QacA family drug resistance transporter (530 aa)
              0.659
Noca_3441
TetR family transcriptional regulator (215 aa)
              0.659
Noca_1516
UvrD/REP helicase (688 aa)
   
   
  0.651
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
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