STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrpLeucine responsive regulator. (151 aa)    
Predicted Functional Partners:
brnF
Branched chain amino acid exporter, large subunit.
  
  
 0.840
brnE
Branched chain amino acid exporter, small subunit.
  
  
 0.840
cg0311
Secreted protein.
       0.615
lysE
Lysine efflux permease; Catalyzes the efflux of L-lysine. Can also export L- arginine and L-citrulline. The lysEG system prevents bacteriostasis due to elevated L-lysine or L-arginine concentrations that arise during growth in the presence of peptides or in mutants possessing a deregulated biosynthesis pathway. In vitro, can also export D-lysine during biotechnological production of D-amino acids.
  
  
 0.612
Cgl0171
PUTATIVE OXIDOREDUCTASE.
      
 0.606
ilvA
THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
      
 0.591
brnQ
Branched-Chain Amino Acid Uptake Carrier; Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force.
   
  
 0.543
gltB
GLUTAMINE 2-OXOGLUTARATE AMINOTRANSFERASE LARGE SU.
     
 0.533
glxR
TRANSCRIPTIONAL REGULATOR, CRP/FNR FAMILY; Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism. May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes. It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole [...]
   
  
 0.480
tdcB
THREONINE DEHYDRATASE.
   
  
 0.463
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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