STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpD1PROPIONATE CATABOLIC PROTEIN PRPD; Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer 2-methyl-aconitate; Belongs to the PrpD family. (498 aa)    
Predicted Functional Partners:
prpC1
(METHYL)CITRATE SYNTHASE; Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with propionyl-CoA but with a lower specificity.
 
 
 0.993
prpC2
METHYLCITRATE SYNTHASE; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity.
 
 
 0.984
prpB1
PROBABLE METHYLISOCITRIC ACID LYASE; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
 
  
 0.949
Cgl2538
MMGE/PRPD FAMILY PROTEIN.
  
  
 
0.927
prpB2
PROBABLE METHYLISOCITRIC ACID LYASE; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate; Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
  
 0.910
ramB
Transcriptional regulator, MerR family; During growth on glucose, RamB negatively controls the expression of aceA, aceB, ack and pta genes which are involved in acetate metabolism. RamB is also a negative regulator of rpf2 gene expression during growth on acetate as the sole carbon source ; Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.
 
  
 0.690
Cgl0698
TRANSCRIPTIONAL REGULATOR, MERR FAMILY.
 
  
 0.574
Cgl0693
FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
       0.542
gltA
CITRATE SYNTHASE.
  
  
 0.472
menG
S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLT; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
   
  
 0.471
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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