STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
relPPGPP SYNTHETASE, PPGPP PYROPHOSPHORYLASE; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities. (760 aa)    
Predicted Functional Partners:
Cgl1177
SIMILAR TO GTP PYROPHOSPHOKINASE.
  
  
 0.933
gmk
PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.912
ppx1
EXOPOLYPHOSPHATASE.
   
 
 0.909
ppx2
EXOPOLYPHOSPHATASE.
   
 
 0.909
ndk
NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.909
Cgl2910
PYRUVATE KINASE-LIKE PROTEIN.
   
 
 0.902
pyk
PYRUVATE KINASE.
     
 0.901
nrdE
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 
 0.901
cyaB
Putative ADENYLATE CYCLASE.
     
 0.900
nrdF
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 BETA CHAIN; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
  0.900
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.