node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl3097 | secA | cg3429 | cg0868 | Preprotein translocase subunit YidC. | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.947 |
Cgl3097 | secA2 | cg3429 | cg1629 | Preprotein translocase subunit YidC. | Similar to preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.983 |
Cgl3097 | secD | cg3429 | cg1867 | Preprotein translocase subunit YidC. | Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.944 |
Cgl3097 | secE | cg3429 | cg0561 | Preprotein translocase subunit YidC. | SecE subunit of protein translocation complex; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.957 |
Cgl3097 | secF | cg3429 | cg1865 | Preprotein translocase subunit YidC. | Preprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.971 |
Cgl3097 | secG | cg3429 | cg1786 | Preprotein translocase subunit YidC. | Preprotein translocase SecG subunit; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | 0.962 |
Cgl3097 | secN | cg3429 | cg1868 | Preprotein translocase subunit YidC. | Preprotein translocase subunit YajC homolog. | 0.981 |
Cgl3097 | secY | cg3429 | cg0647 | Preprotein translocase subunit YidC. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.985 |
Cgl3097 | yidC | cg3429 | cg3252 | Preprotein translocase subunit YidC. | Putative preprotein translocase subunit YidC, SpoIIIJ homolog; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). | 0.923 |
secA | Cgl3097 | cg0868 | cg3429 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit YidC. | 0.947 |
secA | secA2 | cg0868 | cg1629 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Similar to preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.934 |
secA | secD | cg0868 | cg1867 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.937 |
secA | secE | cg0868 | cg0561 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | SecE subunit of protein translocation complex; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.996 |
secA | secF | cg0868 | cg1865 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.728 |
secA | secG | cg0868 | cg1786 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase SecG subunit; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. | 0.996 |
secA | secN | cg0868 | cg1868 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit YajC homolog. | 0.970 |
secA | secY | cg0868 | cg0647 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.999 |
secA | yidC | cg0868 | cg3252 | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Putative preprotein translocase subunit YidC, SpoIIIJ homolog; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). | 0.978 |
secA2 | Cgl3097 | cg1629 | cg3429 | Similar to preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | Preprotein translocase subunit YidC. | 0.983 |
secA2 | secA | cg1629 | cg0868 | Similar to preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | PREPROTEIN TRANSLOCASE SUBUNIT SECA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.934 |