node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | cg2299 | cg2303 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | 0.998 |
hisA | hisC | cg2299 | cg2304 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.985 |
hisA | hisD | cg2299 | cg2305 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | HISTIDINOL DEHYDROGENASE; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisE | cg2299 | cg1699 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | PHOSPHORIBOSYL-ATP CYCLOHYDROLASE. | 0.981 |
hisA | hisF | cg2299 | cg2297 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | PROBABLE CYCLASE (IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE-SUBUNIT); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | cg2299 | cg1698 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | ATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |
hisA | hisH | cg2299 | cg2300 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | IMIDAZOLEGLYCEROL-PHOSPHATE SYNTHASE, AMIDOTRANSFERASE; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | cg2299 | cg2296 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | PROBABLE PHOSPHORIBOSYL-AMP CYCLOHYDROLASE PROTEIN; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisN | cg2299 | cg0910 | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | Inositol monophosphatase; Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. | 0.746 |
hisB | hisA | cg2303 | cg2299 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | 0.998 |
hisB | hisC | cg2303 | cg2304 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | cg2303 | cg2305 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | HISTIDINOL DEHYDROGENASE; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | cg2303 | cg1699 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | PHOSPHORIBOSYL-ATP CYCLOHYDROLASE. | 0.996 |
hisB | hisF | cg2303 | cg2297 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | PROBABLE CYCLASE (IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE-SUBUNIT); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | cg2303 | cg1698 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | ATP PHOSPHORIBOSYLTRANSFERASE; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |
hisB | hisH | cg2303 | cg2300 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | IMIDAZOLEGLYCEROL-PHOSPHATE SYNTHASE, AMIDOTRANSFERASE; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisI | cg2303 | cg2296 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | PROBABLE PHOSPHORIBOSYL-AMP CYCLOHYDROLASE PROTEIN; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.997 |
hisB | hisN | cg2303 | cg0910 | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | Inositol monophosphatase; Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine. | 0.762 |
hisC | hisA | cg2304 | cg2299 | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE RIBOTIDEISOMERASE. | 0.985 |
hisC | hisB | cg2304 | cg2303 | PROBABLE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE. | 0.999 |