node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0839 | aecD | cg0961 | cg2536 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine beta-Lyase. | 0.688 |
Cgl0839 | metB | cg0961 | cg2687 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine gamma-Synthase. | 0.973 |
Cgl0839 | metE | cg0961 | cg1290 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.732 |
Cgl0839 | metH | cg0961 | cg1701 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.475 |
Cgl0839 | metX | cg0961 | cg0754 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family. | 0.955 |
Cgl0839 | metY | cg0961 | cg0755 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | O-Acetylhomoserine (Thiol)-Lyase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (Ref.4,. Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine. Has weak cystathionine gamma-synthase activity. | 0.997 |
Cgl2129 | aecD | cg2337 | cg2536 | Similar to methionine synthase II (cobalamin-independent). | Cystathionine beta-Lyase. | 0.903 |
Cgl2129 | cysK | cg2337 | cg2833 | Similar to methionine synthase II (cobalamin-independent). | O-Acetylserine (Thiol)-Lyase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.840 |
Cgl2129 | metB | cg2337 | cg2687 | Similar to methionine synthase II (cobalamin-independent). | Cystathionine gamma-Synthase. | 0.942 |
Cgl2129 | metE | cg2337 | cg1290 | Similar to methionine synthase II (cobalamin-independent). | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.913 |
Cgl2129 | metH | cg2337 | cg1701 | Similar to methionine synthase II (cobalamin-independent). | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
Cgl2129 | metY | cg2337 | cg0755 | Similar to methionine synthase II (cobalamin-independent). | O-Acetylhomoserine (Thiol)-Lyase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (Ref.4,. Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine. Has weak cystathionine gamma-synthase activity. | 0.919 |
Cgl2129 | sahH | cg2337 | cg0860 | Similar to methionine synthase II (cobalamin-independent). | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.942 |
aecD | Cgl0839 | cg2536 | cg0961 | Cystathionine beta-Lyase. | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 0.688 |
aecD | Cgl2129 | cg2536 | cg2337 | Cystathionine beta-Lyase. | Similar to methionine synthase II (cobalamin-independent). | 0.903 |
aecD | cysK | cg2536 | cg2833 | Cystathionine beta-Lyase. | O-Acetylserine (Thiol)-Lyase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.950 |
aecD | metB | cg2536 | cg2687 | Cystathionine beta-Lyase. | Cystathionine gamma-Synthase. | 0.998 |
aecD | metE | cg2536 | cg1290 | Cystathionine beta-Lyase. | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.933 |
aecD | metH | cg2536 | cg1701 | Cystathionine beta-Lyase. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.918 |
aecD | metX | cg2536 | cg0754 | Cystathionine beta-Lyase. | Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family. | 0.688 |