node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpC | clpP1 | cg2963 | cg2645 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.996 |
clpC | clpP2 | cg2963 | cg2644 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.994 |
clpC | clpS | cg2963 | cg2772 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.789 |
clpC | clpX | cg2963 | cg2620 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | PROBABLE ATP-DEPENDENT PROTEASE (ATP-BINDING SPECIFICITY SUBUNIT); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.860 |
clpC | dnaJ | cg2963 | cg3098 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | CHAPERONE WITH DNAK, HEAT SHOCK PROTEIN (DNAJ PROTEIN); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.617 |
clpC | dnaJ2 | cg2963 | cg2515 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | Molecular chaperone (contain C-terminal Zn finger domain), putative transcriptional repressor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the react [...] | 0.657 |
clpC | dnaK | cg2963 | cg3100 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | Heat shock protein hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.889 |
clpC | grpE | cg2963 | cg3099 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.743 |
clpC | guaB1 | cg2963 | cg2964 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | INOSITOL-MONOPHOSPHATE DEHYDROGENASE. | 0.606 |
clpC | hscA | cg2963 | cg2611 | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | Molecular chaperone, HSP70 family. | 0.818 |
clpP1 | clpC | cg2645 | cg2963 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | 0.996 |
clpP1 | clpP2 | cg2645 | cg2644 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.999 |
clpP1 | clpS | cg2645 | cg2772 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.696 |
clpP1 | clpX | cg2645 | cg2620 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PROBABLE ATP-DEPENDENT PROTEASE (ATP-BINDING SPECIFICITY SUBUNIT); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |
clpP1 | dnaJ | cg2645 | cg3098 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | CHAPERONE WITH DNAK, HEAT SHOCK PROTEIN (DNAJ PROTEIN); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.695 |
clpP1 | dnaJ2 | cg2645 | cg2515 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone (contain C-terminal Zn finger domain), putative transcriptional repressor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the react [...] | 0.541 |
clpP1 | dnaK | cg2645 | cg3100 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.885 |
clpP1 | grpE | cg2645 | cg3099 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.881 |
clpP1 | hscA | cg2645 | cg2611 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone, HSP70 family. | 0.606 |
clpP2 | clpC | cg2644 | cg2963 | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT CLPP2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | PROBABLE ATP-DEPENDENT PROTEASE (HEAT SHOCK PROTEIN); Belongs to the ClpA/ClpB family. | 0.994 |