STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroPAromatic amino acid transport protein; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (457 aa)    
Predicted Functional Partners:
tyrP
Tyrosine-specific transport protein; Involved in transporting tyrosine across the cytoplasmic membrane.
      
 0.806
tyrR
Regulatory protein TyrR; Code: K; COG: COG3283.
      
 0.801
yfiK
Conserved hypothetical protein; Exporter of O-acetylserine (OAS) and cysteine; Belongs to the Rht family.
      
 0.733
ygeD
Putative resistance protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
      
 0.733
yicG
Conserved hypothetical protein; Code: S; COG: COG2860.
      
 0.733
ytfT
Putative transport system permease protein; Code: G; COG: COG1172; Belongs to the binding-protein-dependent transport system permease family.
      
 0.732
mutH
Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family.
      
 0.623
pdhR
Transcriptional regulator for pyruvate dehydrogenase complex; Code: K; COG: COG2186.
      
 0.580
aroF
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, tyrosine repressible); Code: E; COG: COG0722.
      
 0.580
mtr
Tryptophan-specific transport protein; Involved in transporting tryptophan across the cytoplasmic membrane.
      
 0.558
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.