STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yidYPutative transport protein; Code: GEPR; COG: COG0477. (391 aa)    
Predicted Functional Partners:
macA
Putative membrane protein; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. Confers resistance against macrolides (By similarity).
      
 0.739
mdtA
Acriflavin resistance protein AcrA precursor-like protein; Code: Q; COG: COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.719
mdtJ
Possible chaperone; Catalyzes the excretion of spermidine.
      
 0.718
acrD
Aminoglycoside/multidrug efflux system; Similar to Escherichia coli K12 sensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL) gi: 1788812 (567 aa). BLAST with identity of 97% in 563 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.
    
 
 0.715
acrA
Acriflavin resistance protein AcrA precursor; Code: Q; COG: COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.714
fsr
Fosmidomycin resistance protein; Code: GEPR; COG: COG0477.
      
 0.585
emrK
Multidrug resistance protein K; Code: Q; COG: COG1566.
   
 
 0.529
emrD
Multidrug resistance protein D; Code: GEPR; COG: COG0477.
  
   
0.500
ygjI
Putative oxidoreductase; Code: E; COG: COG0531.
  
     0.498
tnaB
Low-affinity tryptophan permease; Code: E; COG: COG0814.
       0.493
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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