STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribFRiboflavin biosynthesis protein ribF; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. (313 aa)    
Predicted Functional Partners:
ribE
Riboflavin synthase alpha chain; Escherichia coli K-12 ortholog: b1662; Escherichia coli O157:H7 ortholog: z2688.
  
 
 0.971
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
  
 0.917
c0929
Protein ybjI; Escherichia coli K-12 ortholog: b0844; Escherichia coli O157:H7 ortholog: z1071.
   
 0.912
yigB
Hypothetical protein yigB; Escherichia coli K-12 ortholog: b3812; Escherichia coli O157:H7 ortholog: z5329.
  
 
 0.912
ycbP
FMN reductase; Escherichia coli K-12 ortholog: b0937; Escherichia coli O157:H7 ortholog: z1285.
    
 0.911
ubiB
NAD(P)H-flavin reductase; Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides; Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.
    
  0.911
appA
Periplasmic appA protein precursor; Escherichia coli K-12 ortholog: b0980; Escherichia coli O157:H7 ortholog: z1397; bifunctional; Phosphoanhydride phosphohydrolase; 6-phytase.
     
  0.900
aphA
Class B acid phosphatase precursor; Escherichia coli K-12 ortholog: b4055; Escherichia coli O157:H7 ortholog: z5654; Belongs to the class B bacterial acid phosphatase family.
     
  0.900
yaaY
Hypothetical protein yaaY; Escherichia coli K-12 ortholog: b0024; Escherichia coli O157:H7 ortholog: z0028.
     
 0.849
ribD
Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
  
 0.846
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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