STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntRTranscriptional regulator mntR; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family. (155 aa)    
Predicted Functional Partners:
mntH
Manganese transport protein mntH; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.
 
  
 0.893
yebN
Hypothetical protein yebN; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
 
   
 0.887
c0902
Hypothetical protein.
     
 0.855
ybiR
Hypothetical protein ybiR; Escherichia coli K-12 ortholog: b0818; Escherichia coli O157:H7 ortholog: z1040.
       0.802
lepB
Signal peptidase I; Escherichia coli K-12 ortholog: b2568; Escherichia coli O157:H7 ortholog: z3850; Belongs to the peptidase S26 family.
   
    0.768
abc
D-methionine transport ATP-binding protein metN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
    
   0.747
hycG
FHL subunit 7; Escherichia coli K-12 ortholog: b2719; Escherichia coli O157:H7 ortholog: z4027.
    
   0.745
yfcH
Hypothetical protein yfcH; Escherichia coli K-12 ortholog: b2304; Escherichia coli O157:H7 ortholog: z3566.
   
    0.638
fur
Ferric uptake regulation protein; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity).
  
  
 0.582
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.
  
  
 0.568
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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