node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carB | pyrB | c0041 | c5345 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrD | c0041 | c1081 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.877 |
carB | pyrE | c0041 | c4466 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.912 |
carB | pyrF | c0041 | c1750 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.942 |
carB | pyrH | c0041 | c0207 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.441 |
carB | upp | c0041 | c3015 | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.569 |
pyrB | carB | c5345 | c0041 | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | 0.999 |
pyrB | pyrD | c5345 | c1081 | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.933 |
pyrB | pyrE | c5345 | c4466 | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.974 |
pyrB | pyrF | c5345 | c1750 | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.970 |
pyrB | upp | c5345 | c3015 | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.737 |
pyrD | carB | c1081 | c0041 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | 0.877 |
pyrD | pyrB | c1081 | c5345 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.933 |
pyrD | pyrE | c1081 | c4466 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.994 |
pyrD | pyrF | c1081 | c1750 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.931 |
pyrD | upp | c1081 | c3015 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.701 |
pyrE | carB | c4466 | c0041 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Carbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. | 0.912 |
pyrE | pyrB | c4466 | c5345 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Aspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.974 |
pyrE | pyrD | c4466 | c1081 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.994 |
pyrE | pyrF | c4466 | c1750 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.997 |