node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eda | edd | c2263 | c2264 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.998 |
eda | gapA | c2263 | c2184 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.845 |
eda | glk | c2263 | c2927 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. | 0.929 |
eda | gnd | c2263 | c2556 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.707 |
eda | pgi | c2263 | c4991 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Glucose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b4025; Escherichia coli O157:H7 ortholog: z5623. | 0.883 |
eda | pgm | c2263 | c0775 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Phosphoglucomutase; Escherichia coli K-12 ortholog: b0688; Escherichia coli O157:H7 ortholog: z0837. | 0.807 |
eda | pykA | c2263 | c2268 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Pyruvate kinase II; Escherichia coli K-12 ortholog: b1854; Escherichia coli O157:H7 ortholog: z2906; Belongs to the pyruvate kinase family. | 0.872 |
eda | pykF | c2263 | c2071 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Pyruvate kinase I; Escherichia coli K-12 ortholog: b1676; Escherichia coli O157:H7 ortholog: z2704; Belongs to the pyruvate kinase family. | 0.840 |
eda | zwf | c2263 | c2265 | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.972 |
edd | eda | c2264 | c2263 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | 0.998 |
edd | gapA | c2264 | c2184 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.483 |
edd | glk | c2264 | c2927 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. | 0.866 |
edd | gnd | c2264 | c2556 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.967 |
edd | pgi | c2264 | c4991 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b4025; Escherichia coli O157:H7 ortholog: z5623. | 0.671 |
edd | pykA | c2264 | c2268 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Pyruvate kinase II; Escherichia coli K-12 ortholog: b1854; Escherichia coli O157:H7 ortholog: z2906; Belongs to the pyruvate kinase family. | 0.730 |
edd | pykF | c2264 | c2071 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Pyruvate kinase I; Escherichia coli K-12 ortholog: b1676; Escherichia coli O157:H7 ortholog: z2704; Belongs to the pyruvate kinase family. | 0.457 |
edd | ybhE | c2264 | c0844 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Hypothetical protein ybhE; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. | 0.906 |
edd | zwf | c2264 | c2265 | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.984 |
gapA | eda | c2184 | c2263 | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. | 0.845 |
gapA | edd | c2184 | c2264 | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.483 |