node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceB | c2988 | c4971 | c2988 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | 0.960 |
aceB | fumA | c4971 | c2004 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. | 0.915 |
aceB | fumB | c4971 | c5127 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.915 |
aceB | fumC | c4971 | c2003 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.916 |
aceB | gltA | c4971 | c0796 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Citrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. | 0.978 |
aceB | mdh | c4971 | c3991 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.935 |
aceB | pckA | c4971 | c4176 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. | 0.908 |
aceB | ppc | c4971 | c4915 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. | 0.933 |
aceB | sfcA | c4971 | c1912 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | NAD-dependent malic enzyme; Escherichia coli K-12 ortholog: b1479; Escherichia coli O157:H7 ortholog: z2231; Belongs to the malic enzymes family. | 0.912 |
aceB | yojH | c4971 | c2751 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Malate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. | 0.915 |
c2988 | aceB | c2988 | c4971 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | 0.960 |
c2988 | fumA | c2988 | c2004 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. | 0.977 |
c2988 | fumB | c2988 | c5127 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.976 |
c2988 | fumC | c2988 | c2003 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.969 |
c2988 | gltA | c2988 | c0796 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Citrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. | 0.912 |
c2988 | mdh | c2988 | c3991 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.960 |
c2988 | pckA | c2988 | c4176 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. | 0.869 |
c2988 | ppc | c2988 | c4915 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. | 0.682 |
c2988 | sfcA | c2988 | c1912 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | NAD-dependent malic enzyme; Escherichia coli K-12 ortholog: b1479; Escherichia coli O157:H7 ortholog: z2231; Belongs to the malic enzymes family. | 0.909 |
c2988 | yojH | c2988 | c2751 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | Malate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. | 0.935 |