STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alaAProbable aminotransferase yfbQ; Involved in the biosynthesis of alanine. (405 aa)    
Predicted Functional Partners:
avtA
Valine--pyruvate aminotransferase; Escherichia coli K-12 ortholog: b3572; Escherichia coli O157:H7 ortholog: z4997.
     
 0.966
ilvD
Dihydroxy-acid dehydratase; Escherichia coli K-12 ortholog: b3771; Escherichia coli O157:H7 ortholog: z5282.
  
 
 0.915
aspC
Aspartate aminotransferase; Escherichia coli K-12 ortholog: b0928; Escherichia coli O157:H7 ortholog: z1275.
   
 0.914
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine.
  
 
 0.914
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.913
gdhA
NADP-specific glutamate dehydrogenase; Escherichia coli K-12 ortholog: b1761; Escherichia coli O157:H7 ortholog: z2793; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.913
argA
Amino-acid acetyltransferase; Escherichia coli K-12 ortholog: b2818; Escherichia coli O157:H7 ortholog: z4135; Belongs to the acetyltransferase family. ArgA subfamily.
  
 
 0.913
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
  
  0.826
icdA
Isocitrate dehydrogenase (NADP); Escherichia coli K-12 ortholog: b1136; Escherichia coli O157:H7 ortholog: z1865.
   
 0.826
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.820
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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