STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fabB3-oxoacyl-[acyl-carrier-protein] synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity). (406 aa)    
Predicted Functional Partners:
fabD
Malonyl CoA-acyl carrier protein transacylase; Escherichia coli K-12 ortholog: b1092; Escherichia coli O157:H7 ortholog: z1731; Belongs to the FabD family.
 0.997
fabI
Enoyl-[acyl-carrier-protein] reductase (NADH); Escherichia coli K-12 ortholog: b1288; Escherichia coli O157:H7 ortholog: z2512.
 
 
 0.996
c2463
Putative transacylase; Residues 4 to 392 of 422 are 29.30 pct identical to residues 3 to 374 of 400 from GenPept.129 : >dbj|BAB69697.1| (AB050629) putative malonyl-CoA transacylase [Bacillus subtilis].
 0.995
fabA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
 
 
 0.994
c1689
Hypothetical protein; Residues 176 to 347 of 347 are 80.81 pct identical to residues 4 to 175 of 175 from GenPept.129 : >emb|CAA21325.1| (AL031866) ORF3, len: 175 aa,similar to C-terminal end of XCU70053_2 Xanthomonas campestris gumO (435 aa), possible frameshift, this ORF is the prolongation of ORF 4 also similar to XCU70053_2. Fasta score: opt: 367, E(): 1.8e-17 39.5%identity in 172 aa overlap [Yersinia pestis].
 
 
 0.989
fabH
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
 
 
 0.987
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
 
 
 0.984
c1187
3-oxoacyl-[acyl-carrier protein] reductase; Escherichia coli K-12 ortholog: b1093; Escherichia coli O157:H7 ortholog: z4865.
 
 0.982
fabZ
(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
 
 
 0.981
c1189
Putative 3-oxoacyl-[ACP] synthase; Escherichia coli O157:H7 ortholog: z4863; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
  
 
0.925
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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