STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsdAD-serine dehydratase; Escherichia coli K-12 ortholog: b2366; Escherichia coli O157:H7 ortholog: z3628. (442 aa)    
Predicted Functional Partners:
dsdX
DsdX permease; Protein that allows transport of D-serine across the inner membrane, does not transport D-alanine nor probably glycine. Is probably a H(+) symporter, as CCCP inhibits transport. Transports D- serine more efficiently than CycA; Belongs to the GntP permease family.
  
  
 0.977
sdaA
L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z2857; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
 0.958
sdaB
L-serine dehydratase 2; Escherichia coli K-12 ortholog: b2797; Escherichia coli O157:H7 ortholog: z4114; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
 0.958
c3870
L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z4464; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
 0.915
tdcB
Threonine dehydratase catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to y [...]
     
 0.906
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.906
ycdW
Putative 2-hydroxyacid dehydrogenase ycdW; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
     
  0.800
aldA
Aldehyde dehydrogenase A; Escherichia coli K-12 ortholog: b1415; Escherichia coli O157:H7 ortholog: z2306; Belongs to the aldehyde dehydrogenase family.
     
  0.800
gloA
Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
     
  0.800
yedU
Protein yedU; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing th [...]
     
  0.800
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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