STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmpAFlavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)    
Predicted Functional Partners:
ytfE
Hypothetical protein ytfE; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions.
  
  
 0.994
yjeB
Hypothetical protein yjeB; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.
 
   
 0.929
ybjW
Prismane protein homolog; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
  
 0.877
nrfA
Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.
     
 0.836
ygaA
Hypothetical sigma-54-dependent transcriptional regulator ygaA; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
     
 0.828
ygbD
FlRd-NAD(+) reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
  
  
 0.787
yeaR
Hypothetical protein yeaR; Escherichia coli K-12 ortholog: b1797; Escherichia coli O157:H7 ortholog: z2839.
  
  
 0.743
nirB
Nitrite reductase [NAD(P)H] large subunit; Escherichia coli K-12 ortholog: b3365; Escherichia coli O157:H7 ortholog: z4726; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.732
ubiB
NAD(P)H-flavin reductase; Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides; Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.
     
 0.635
aer
Aerotaxis receptor; Escherichia coli K-12 ortholog: b3072; Escherichia coli O157:H7 ortholog: z4425.
     
 0.632
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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