STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
kpsFHypothetical protein yrbH; Involved in the biosynthesis of K-antigen capsules. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). Belongs to the SIS family. GutQ/KpsF subfamily. (339 aa)    
Predicted Functional Partners:
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; Escherichia coli K-12 ortholog: b1215; Escherichia coli O157:H7 ortholog: z1986; Belongs to the KdsA family.
 
 
 0.979
c3406
Phosphosugar isomerase; Residues 1 to 195 of 198 are 44.10 pct identical to residues 1 to 195 of 322 from SwissProt.40 : >sp|O67500|YF46_AQUAE Hypothetical protein AQ_1546.
  
  
0.913
kdsD
Hypothetical protein yrbH; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).
 
  
 
0.913
kdsB-2
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.896
yrbI
Hypothetical protein yrbI; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family.
  
 0.794
kdsB
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.791
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
 
   
 0.738
kpsS
KpsS protein; Residues 1 to 389 of 412 are 97.17 pct identical to residues 1 to 389 of 389 from SwissProt.40 : >sp|P42218|KSS5_ECOLI CAPSULE POLYSACCHARIDE EXPORT PROTEIN KPSS.
     
 0.732
kpsE
KpsE protein; Involved in the translocation of the polysialic acid capsule. Belongs to the BexC/CtrB/KpsE family.
     
 0.728
lpxA
Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.722
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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