node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceA | aceB | c4972 | c4971 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | 0.999 |
aceA | acs | c4972 | c5064 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.762 |
aceA | c2988 | c4972 | c2988 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | 0.713 |
aceA | eutI | c4972 | c2983 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Ethanolamine utilization protein eutD; Escherichia coli K-12 ortholog: b2458; Escherichia coli O157:H7 ortholog: z3714. | 0.544 |
aceA | gcl | c4972 | c0622 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Glyoxylate carboligase; Escherichia coli K-12 ortholog: b0507; Escherichia coli O157:H7 ortholog: z0661; Belongs to the TPP enzyme family. | 0.915 |
aceA | glcB | c4972 | c3705 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.995 |
aceA | glcD | c4972 | c3709 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Glycolate oxidase subunit glcD; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)- lactate) with a similar rate. Does not link directly to O(2), and 2,6- dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | 0.906 |
aceA | gltA | c4972 | c0796 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Citrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. | 0.850 |
aceA | pta | c4972 | c2840 | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.831 |
aceB | aceA | c4971 | c4972 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 0.999 |
aceB | acs | c4971 | c5064 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.954 |
aceB | c2988 | c4971 | c2988 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. | 0.960 |
aceB | eutI | c4971 | c2983 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Ethanolamine utilization protein eutD; Escherichia coli K-12 ortholog: b2458; Escherichia coli O157:H7 ortholog: z3714. | 0.939 |
aceB | gcl | c4971 | c0622 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Glyoxylate carboligase; Escherichia coli K-12 ortholog: b0507; Escherichia coli O157:H7 ortholog: z0661; Belongs to the TPP enzyme family. | 0.913 |
aceB | glcB | c4971 | c3705 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.966 |
aceB | glcD | c4971 | c3709 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Glycolate oxidase subunit glcD; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)- lactate) with a similar rate. Does not link directly to O(2), and 2,6- dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. | 0.913 |
aceB | gltA | c4971 | c0796 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Citrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. | 0.978 |
aceB | pta | c4971 | c2840 | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.959 |
acs | aceA | c5064 | c4972 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 0.762 |
acs | aceB | c5064 | c4971 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. | 0.954 |