node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hybB | hybC | c3732 | c3731 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.999 |
hybB | hybD | c3732 | c3730 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | 0.937 |
hybB | hybE | c3732 | c3729 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Hydrogenase-2 operon protein hybE; Escherichia coli K-12 ortholog: b2992; Escherichia coli O157:H7 ortholog: z4346; Belongs to the HupJ family. | 0.981 |
hybB | hybF | c3732 | c3728 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Probable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.851 |
hybB | hybG | c3732 | c3727 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Hydrogenase-2 operon protein hybG; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron- bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Belongs to the HupF/HypC family. | 0.794 |
hybB | hybO | c3732 | c3734 | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. | 0.999 |
hybC | hybB | c3731 | c3732 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | 0.999 |
hybC | hybD | c3731 | c3730 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | 0.990 |
hybC | hybE | c3731 | c3729 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase-2 operon protein hybE; Escherichia coli K-12 ortholog: b2992; Escherichia coli O157:H7 ortholog: z4346; Belongs to the HupJ family. | 0.971 |
hybC | hybF | c3731 | c3728 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Probable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.971 |
hybC | hybG | c3731 | c3727 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase-2 operon protein hybG; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron- bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Belongs to the HupF/HypC family. | 0.962 |
hybC | hybO | c3731 | c3734 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. | 0.999 |
hybC | hypB | c3731 | c3287 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase isoenzymes nickel incorporation protein hypB; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. | 0.819 |
hybC | hypD | c3731 | c3289 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase isoenzymes formation protein hypD; Escherichia coli K-12 ortholog: b2729; Escherichia coli O157:H7 ortholog: z4038; Belongs to the HypD family. | 0.836 |
hybC | hypE | c3731 | c3290 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase isoenzymes formation protein hypE; Escherichia coli K-12 ortholog: b2730; Escherichia coli O157:H7 ortholog: z4039. | 0.754 |
hybC | hypF | c3731 | c3268 | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase maturation protein hypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.903 |
hybD | hybB | c3730 | c3732 | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | Probable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. | 0.937 |
hybD | hybC | c3730 | c3731 | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.990 |
hybD | hybE | c3730 | c3729 | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | Hydrogenase-2 operon protein hybE; Escherichia coli K-12 ortholog: b2992; Escherichia coli O157:H7 ortholog: z4346; Belongs to the HupJ family. | 0.970 |
hybD | hybF | c3730 | c3728 | Hydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. | Probable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.947 |