node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
c1862 | higA | c1862 | c3840 | Hypothetical protein; Residues 1 to 67 of 67 are 95.52 pct identical to residues 79 to 145 of 145 from GenPept.129 : >gb|AAC74520.1| (AE000241) orf, hypothetical protein [Escherichia coli K12]. | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | 0.822 |
c1862 | higB | c1862 | c3274 | Hypothetical protein; Residues 1 to 67 of 67 are 95.52 pct identical to residues 79 to 145 of 145 from GenPept.129 : >gb|AAC74520.1| (AE000241) orf, hypothetical protein [Escherichia coli K12]. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | 0.818 |
c1862 | yefM | c1862 | c2545 | Hypothetical protein; Residues 1 to 67 of 67 are 95.52 pct identical to residues 79 to 145 of 145 from GenPept.129 : >gb|AAC74520.1| (AE000241) orf, hypothetical protein [Escherichia coli K12]. | Hypothetical protein yefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). | 0.407 |
c3841 | higA | c3841 | c3840 | Hypothetical protein; Residues 32 to 56 of 56 are 100.00 pct identical to residues 80 to 104 of 104 from GenPept.129 : >gb|AAG58216.1|AE005538_3 (AE005538) orf, hypothetical protein [Escherichia coli O157:H7 EDL933]. | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | 0.933 |
higA | c1862 | c3840 | c1862 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein; Residues 1 to 67 of 67 are 95.52 pct identical to residues 79 to 145 of 145 from GenPept.129 : >gb|AAC74520.1| (AE000241) orf, hypothetical protein [Escherichia coli K12]. | 0.822 |
higA | c3841 | c3840 | c3841 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein; Residues 32 to 56 of 56 are 100.00 pct identical to residues 80 to 104 of 104 from GenPept.129 : >gb|AAG58216.1|AE005538_3 (AE005538) orf, hypothetical protein [Escherichia coli O157:H7 EDL933]. | 0.933 |
higA | higB | c3840 | c3274 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | 0.999 |
higA | hipB | c3840 | c1941 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Protein hipB; Antitoxin component of a type II type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Represses the hipBA operon promoter (By similarity). | 0.736 |
higA | parE | c3840 | c3776 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.682 |
higA | yaaW | c3840 | c0016 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein yaaW; Escherichia coli K-12 ortholog: b0011; Escherichia coli O157:H7 ortholog: z0011. | 0.569 |
higA | yddM | c3840 | c1909 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein yddM; Escherichia coli K-12 ortholog: b1477; Escherichia coli O157:H7 ortholog: z2233; Belongs to the VapA/VapI family. | 0.730 |
higA | yefM | c3840 | c2545 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein yefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). | 0.725 |
higA | yfaT | c3840 | c2771 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein yfaT precursor; Escherichia coli K-12 ortholog: b2229; Escherichia coli O157:H7 ortholog: z3482. | 0.552 |
higA | yoeB | c3840 | c2544 | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). | 0.715 |
higB | c1862 | c3274 | c1862 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Hypothetical protein; Residues 1 to 67 of 67 are 95.52 pct identical to residues 79 to 145 of 145 from GenPept.129 : >gb|AAC74520.1| (AE000241) orf, hypothetical protein [Escherichia coli K12]. | 0.818 |
higB | higA | c3274 | c3840 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. | 0.999 |
higB | hipB | c3274 | c1941 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Protein hipB; Antitoxin component of a type II type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Represses the hipBA operon promoter (By similarity). | 0.572 |
higB | parE | c3274 | c3776 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.588 |
higB | yddM | c3274 | c1909 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Hypothetical protein yddM; Escherichia coli K-12 ortholog: b1477; Escherichia coli O157:H7 ortholog: z2233; Belongs to the VapA/VapI family. | 0.606 |
higB | yefM | c3274 | c2545 | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. | Hypothetical protein yefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). | 0.814 |