node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
nagA | nagB | c0752 | c0753 | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.999 |
nagA | nanA | c0752 | c3979 | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | 0.445 |
nagA | nanK1 | c0752 | c3976 | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. | 0.736 |
nagA | nanT | c0752 | c3978 | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. | 0.568 |
nagA | yhcJ | c0752 | c3977 | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.978 |
nagB | nagA | c0753 | c0752 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | 0.999 |
nagB | nanA | c0753 | c3979 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | 0.688 |
nagB | nanK1 | c0753 | c3976 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. | 0.823 |
nagB | nanT | c0753 | c3978 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. | 0.682 |
nagB | yhcH | c0753 | c3975 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | Hypothetical protein yhcH; Escherichia coli K-12 ortholog: b3221; Escherichia coli O157:H7 ortholog: z4579. | 0.428 |
nagB | yhcJ | c0753 | c3977 | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.857 |
nanA | nagA | c3979 | c0752 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | N-acetylglucosamine-6-phosphate deacetylase; Escherichia coli K-12 ortholog: b0677; Escherichia coli O157:H7 ortholog: z0824. | 0.445 |
nanA | nagB | c3979 | c0753 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.688 |
nanA | nanA2 | c3979 | c3639 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | 0.901 |
nanA | nanK1 | c3979 | c3976 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. | 0.996 |
nanA | nanK2 | c3979 | c3638 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. | 0.942 |
nanA | nanT | c3979 | c3978 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. | 0.971 |
nanA | yhcH | c3979 | c3975 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yhcH; Escherichia coli K-12 ortholog: b3221; Escherichia coli O157:H7 ortholog: z4579. | 0.897 |
nanA | yhcJ | c3979 | c3977 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.978 |
nanA | yhcK | c3979 | c3980 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical transcriptional regulator yhcK; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. | 0.906 |