STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ompRTranscriptional Regulatory protein ompR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. (239 aa)    
Predicted Functional Partners:
envZ
Osmolarity sensor protein envZ; Escherichia coli K-12 ortholog: b3404; Escherichia coli O157:H7 ortholog: z4759.
 
 0.999
arcB
Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574.
 
 0.934
cpxA
Sensor protein cpxA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity).
 
 
 0.914
barA
Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity).
 
 
 0.864
torS
Sensor protein torS; Escherichia coli K-12 ortholog: b0993; Escherichia coli O157:H7 ortholog: z1410.
 
 
 0.825
phoR
Phosphate regulon sensor protein phoR; Escherichia coli K-12 ortholog: b0400; Escherichia coli O157:H7 ortholog: z0498.
 
 0.810
evgS
Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632.
 
 
0.801
cusS
Sensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation.
 
 
 0.758
phoQ
Sensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...]
 
 
 0.732
yedV
Putative sensor-like histidine kinase yedV; Member of a two-component regulatory system.
 
 
 0.692
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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