node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arcB | barA | c3970 | c3349 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | 0.997 |
arcB | cpxA | c3970 | c4863 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor protein cpxA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity). | 0.827 |
arcB | cusS | c3970 | c0656 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.641 |
arcB | envZ | c3970 | c4180 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Osmolarity sensor protein envZ; Escherichia coli K-12 ortholog: b3404; Escherichia coli O157:H7 ortholog: z4759. | 0.832 |
arcB | evgS | c3970 | c2906 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | 0.996 |
arcB | ompR | c3970 | c4181 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Transcriptional Regulatory protein ompR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. | 0.934 |
arcB | phoQ | c3970 | c1508 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] | 0.820 |
arcB | phoR | c3970 | c0509 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Phosphate regulon sensor protein phoR; Escherichia coli K-12 ortholog: b0400; Escherichia coli O157:H7 ortholog: z0498. | 0.669 |
arcB | torS | c3970 | c1128 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Sensor protein torS; Escherichia coli K-12 ortholog: b0993; Escherichia coli O157:H7 ortholog: z1410. | 0.993 |
arcB | yedV | c3970 | c2386 | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | Putative sensor-like histidine kinase yedV; Member of a two-component regulatory system. | 0.686 |
barA | arcB | c3349 | c3970 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. | 0.997 |
barA | cpxA | c3349 | c4863 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor protein cpxA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity). | 0.757 |
barA | cusS | c3349 | c0656 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.673 |
barA | envZ | c3349 | c4180 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Osmolarity sensor protein envZ; Escherichia coli K-12 ortholog: b3404; Escherichia coli O157:H7 ortholog: z4759. | 0.740 |
barA | evgS | c3349 | c2906 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. | 0.992 |
barA | ompR | c3349 | c4181 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Transcriptional Regulatory protein ompR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. | 0.864 |
barA | phoQ | c3349 | c1508 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] | 0.835 |
barA | phoR | c3349 | c0509 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Phosphate regulon sensor protein phoR; Escherichia coli K-12 ortholog: b0400; Escherichia coli O157:H7 ortholog: z0498. | 0.677 |
barA | torS | c3349 | c1128 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Sensor protein torS; Escherichia coli K-12 ortholog: b0993; Escherichia coli O157:H7 ortholog: z1410. | 0.985 |
barA | yedV | c3349 | c2386 | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). | Putative sensor-like histidine kinase yedV; Member of a two-component regulatory system. | 0.786 |