node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobB | mazG | c1395 | c3346 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | 0.901 |
cobB | nadE | c1395 | c2139 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.926 |
cobB | udhA | c1395 | c4923 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. | 0.911 |
cobB | ybeN | c1395 | c0730 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.926 |
cobB | yfjB | c1395 | c3137 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.922 |
cobB | yjaD | c1395 | c4953 | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | NADH pyrophosphatase; Escherichia coli K-12 ortholog: b3996; Escherichia coli O157:H7 ortholog: z5571. | 0.904 |
mazG | cobB | c3346 | c1395 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | 0.901 |
mazG | nadE | c3346 | c2139 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.900 |
mazG | pncB | c3346 | c1073 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.916 |
mazG | surE | c3346 | c3311 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Acid phosphatase surE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.904 |
mazG | udhA | c3346 | c4923 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. | 0.916 |
mazG | ushA | c3346 | c0600 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Protein ushA precursor; Escherichia coli K-12 ortholog: b0480; Escherichia coli O157:H7 ortholog: z0599; bifunctional; UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
mazG | ybeN | c3346 | c0730 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.903 |
mazG | yfjB | c3346 | c3137 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.902 |
mazG | ygaD | c3346 | c3254 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | Protein ygaD; Has NMN aminohydrolase activity, not active on other substrates. | 0.912 |
mazG | yjaD | c3346 | c4953 | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | NADH pyrophosphatase; Escherichia coli K-12 ortholog: b3996; Escherichia coli O157:H7 ortholog: z5571. | 0.910 |
nadE | cobB | c2139 | c1395 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | CobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. | 0.926 |
nadE | mazG | c2139 | c3346 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | MazG protein; Escherichia coli K-12 ortholog: b2781; Escherichia coli O157:H7 ortholog: z4096. | 0.900 |
nadE | pncB | c2139 | c1073 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.890 |
nadE | udhA | c2139 | c4923 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. | 0.902 |