STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnOGluconate 5-dehydrogenase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)    
Predicted Functional Partners:
idnD
L-idonate 5-dehydrogenase; Escherichia coli K-12 ortholog: b4267.
 
 
 0.972
idnK
Thermosensitive gluconokinase; Escherichia coli K-12 ortholog: b4268; Escherichia coli O157:H7 ortholog: z4805.
  
 
 0.814
nuoC
NADH dehydrogenase I chain C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 
 0.695
kduI
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
 
  
 0.692
idnT
Gnt-II system L-idonate transporter; L-Ido transporter; Escherichia coli K-12 ortholog: b4265; Escherichia coli O157:H7 ortholog: z4770.
 
  
 0.683
idnR
L-idonate Regulatory protein; Escherichia coli K-12 ortholog: b4264; Escherichia coli O157:H7 ortholog: z4806.
  
 
 0.577
gntK
Thermoresistant gluconokinase; Escherichia coli K-12 ortholog: b3437; Escherichia coli O157:H7 ortholog: z4805.
  
 
 0.556
c2670
Putative conserved protein; Residues 1 to 102 of 102 are 99.01 pct identical to residues 1 to 102 of 253 from MG1655 : b2137.
  
     0.531
yiaE
2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
 
 0.527
entB
Isochorismatase; Escherichia coli K-12 ortholog: b0595; Escherichia coli O157:H7 ortholog: z0737.
  
  
 0.437
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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