node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
c1274 | c2439 | c1274 | c2439 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | 0.776 |
c1274 | nanM2 | c1274 | c5388 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.673 |
c1274 | yheK | c1274 | c4104 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Probable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633. | 0.774 |
c1274 | yihF | c1274 | c4806 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein yihF; Escherichia coli K-12 ortholog: b3861; Escherichia coli O157:H7 ortholog: z5393. | 0.771 |
c2439 | c1274 | c2439 | c1274 | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | 0.776 |
c2439 | c3664 | c2439 | c3664 | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | 0.776 |
c2439 | nanM2 | c2439 | c5388 | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.690 |
c2439 | yheK | c2439 | c4104 | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | Probable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633. | 0.774 |
c2439 | yihF | c2439 | c4806 | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | Hypothetical protein yihF; Escherichia coli K-12 ortholog: b3861; Escherichia coli O157:H7 ortholog: z5393. | 0.772 |
c3664 | c2439 | c3664 | c2439 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12]. | 0.776 |
c3664 | nanM2 | c3664 | c5388 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.676 |
c3664 | yheK | c3664 | c4104 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Probable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633. | 0.774 |
c3664 | yihF | c3664 | c4806 | Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001. | Hypothetical protein yihF; Escherichia coli K-12 ortholog: b3861; Escherichia coli O157:H7 ortholog: z5393. | 0.771 |
c5387 | nanA | c5387 | c3979 | Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905. | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | 0.681 |
c5387 | nanC | c5387 | c5389 | Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905. | Hypothetical protein yjhA precursor; Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity (By similarity). | 0.687 |
c5387 | nanM2 | c5387 | c5388 | Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905. | Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.897 |
c5387 | yhcJ | c5387 | c3977 | Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905. | Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.411 |
nanA | c5387 | c3979 | c5387 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905. | 0.681 |
nanA | nanC | c3979 | c5389 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yjhA precursor; Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity (By similarity). | 0.824 |
nanA | nanM2 | c3979 | c5388 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. | Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.746 |