STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nanM2Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (404 aa)    
Predicted Functional Partners:
nanC
Hypothetical protein yjhA precursor; Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity (By similarity).
  
  
 0.955
c5387
Hypothetical protein yjhS precursor; Escherichia coli K-12 ortholog: b4309; Escherichia coli O157:H7 ortholog: z5905.
  
  
 0.897
nanT
Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
  
  
 0.860
nanA
N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
 
  
 0.746
yhcJ
Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
  
 0.696
c2439
Hypothetical protein; Residues 35 to 487 of 489 are 26.20 pct identical to residues 531 to 997 of 2383 from GenPept.129 : >gb|AAC75042.1| (AE000289) putative factor [Escherichia coli K12].
  
     0.690
c3664
Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001.
  
     0.676
yihF
Hypothetical protein yihF; Escherichia coli K-12 ortholog: b3861; Escherichia coli O157:H7 ortholog: z5393.
  
     0.674
c1274
Hypothetical protein yeeR; Escherichia coli K-12 ortholog: b2001.
  
     0.673
yheK
Probable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633.
  
     0.660
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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