STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cthe_0285KEGG: tit:Thit_0372 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (402 aa)    
Predicted Functional Partners:
Cthe_3158
KEGG: cce:Ccel_2176 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein.
  
 0.994
Cthe_0374
PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: cce:Ccel_2430 Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.969
Cthe_3027
PFAM: Citrate synthase; KEGG: dae:Dtox_1989 citrate (Si)-synthase.
  
 
 0.965
Cthe_0866
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cce:Ccel_0554 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
   
 
 0.917
Cthe_0864
PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: cce:Ccel_0556 pyruvate ferredoxin/flavodoxin oxidoreductase.
   
 
 0.913
Cthe_0865
PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: cce:Ccel_0555 thiamine pyrophosphate protein domain protein TPP-binding.
   
 
 0.912
Cthe_0867
KEGG: cce:Ccel_0553 4Fe-4S ferredoxin iron-sulfur binding domain protein.
   
 
  0.901
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.900
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 
 0.896
fhs
KEGG: cce:Ccel_0018 formate-tetrahydrofolate ligase FTHFS; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family.
 
 
  
 0.896
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.