STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (407 aa)    
Predicted Functional Partners:
Cthe_0368
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: cce:Ccel_2205 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase.
  
 0.988
Cthe_1841
PFAM: PP-loop domain protein; KEGG: cce:Ccel_0923 ExsB family protein.
  
 0.988
Cthe_0370
TIGRFAM: conserved hypothetical protein; PFAM: Radical SAM domain protein; KEGG: cce:Ccel_2203 hypothetical protein; SMART: Elongator protein 3/MiaB/NifB.
  
    0.787
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
 
      0.717
Cthe_0367
PFAM: Domain of unknown function DUF2520; NADP oxidoreductase coenzyme F420-dependent; KEGG: chy:CHY_2378 hypothetical protein.
  
    0.659
Cthe_1803
PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: hmo:HM1_3002 cobalamin biosynthesis protein CbiM.
 
    0.622
Cthe_1802
KEGG: hmo:HM1_3001 cobalt abc transporter, permease protein CbiQ; TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein.
 
    0.552
Cthe_0236
PFAM: aldo/keto reductase; KEGG: cce:Ccel_2503 aldo/keto reductase.
 
    0.430
Cthe_1172
KEGG: bhy:BHWA1_02617 hypothetical protein.
 
     0.405
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
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