STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cthe_0912Glycoside hydrolase family 10; KEGG: cpy:Cphy_0624 endo-1,4-beta-xylanase; PFAM: glycoside hydrolase family 10; Carbohydrate-binding CenC domain protein; Dockerin type 1; esterase; SMART: glycoside hydrolase family 10. (1077 aa)    
Predicted Functional Partners:
cipA
Cellulosome anchoring protein cohesin region; Acts as a scaffolding protein in the cellulosome. It promotes binding of cellulose to the catalytic domains of the cellulolytic enzymes.
  
 
 0.954
Cthe_1271
KEGG: cce:Ccel_1229 carbohydrate binding family 6; PFAM: Carbohydrate binding family 6; glycoside hydrolase family 43; Dockerin type 1; SMART: cellulose binding type IV.
   
0.936
rsgI6
Glycoside hydrolase family 10; Anti-sigma factor for SigI6. Negatively regulates SigI6 activity through direct interaction. Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI6 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI6 (By similarity). Binds to and hydrolyzes insoluble and soluble xylan substrates. Has low enzymatic activity ; In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.
 
   0.911
xynZ
Glycoside hydrolase family 10; KEGG: cce:Ccel_1232 carbohydrate binding family 6; PFAM: glycoside hydrolase family 10; Carbohydrate binding family 6; esterase; Dockerin type 1; SMART: glycoside hydrolase family 10; cellulose binding type IV.
 
 
 
0.896
Cthe_2196
Glycoside hydrolase family 43; KEGG: cce:Ccel_1231 carbohydrate binding family 6; PFAM: glycoside hydrolase family 43; Carbohydrate binding family 6; Dockerin type 1; SMART: cellulose binding type IV; Belongs to the glycosyl hydrolase 43 family.
   
0.888
Cthe_2548
alpha-L-arabinofuranosidase domain protein; Involved in the degradation of arabinan and is a key enzyme in the complete degradation of the plant cell wall. Catalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in small oligosaccharides as alpha-(1->5)-linked arabinobiose/arabinotriose, but does not display significant activity against linear non-substituted arabinan. It is also highly efficient in the cleavage of alpha-(1->3)- linked arabinoside of xylobiose and of the alpha-(1->3)-linked arabinoside decorations of polymeric wheat arabinoxylan. It exhibits very low act [...]
 
   
 0.690
celC
Glycoside hydrolase family 5; This enzyme catalyzes the endohydrolysis of 1,4-beta- glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
 
  
 0.687
Cthe_1904
KEGG: hau:Haur_3129 amino acid adenylation domain-containing protein; TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; major facilitator superfamily MFS_1; condensation domain protein; Thioesterase; phosphopantetheine-binding; Belongs to the ATP-dependent AMP-binding enzyme family.
 
  
 0.682
Cthe_0071
KEGG: cpy:Cphy_3368 cellulose 1,4-beta-cellobiosidase; PFAM: glycoside hydrolase family 48; type 3a cellulose-binding domain protein.
 
   
 0.593
Cthe_0135
PFAM: Acyl transferase; Beta-ketoacyl synthase; phosphopantetheine-binding; KR domain protein; KEGG: sus:Acid_3077 beta-ketoacyl synthase.
  
  
 0.593
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
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