STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uppPUndecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa)    
Predicted Functional Partners:
Cthe_1001
Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
     
 0.927
mraY
phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
    
 0.916
Cthe_2680
Peptidase S41; KEGG: cpy:Cphy_1188 peptidase S41; PFAM: peptidase S41; Tetratricopeptide TPR_1 repeat-containing protein; SMART: peptidase S41; Tetratricopeptide repeat.
     
 0.535
Cthe_2306
MATE efflux family protein; KEGG: cpo:COPRO5265_0068 Na+-driven multidrug efflux pump; TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE.
  
  
 0.534
Cthe_0681
IMP dehydrogenase; KEGG: bbe:BBR47_06650 inosine-5'-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein.
 
   
 0.449
Cthe_1226
PFAM: dihydrofolate reductase region; KEGG: cdl:CDR20291_0044 dihydrofolate reductase region.
     
 0.440
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
    0.428
Cthe_2204
KEGG: cce:Ccel_0132 cyanophycin synthetase; TIGRFAM: cyanophycin synthetase; PFAM: Mur ligase middle domain protein; RimK domain protein ATP-grasp; cytoplasmic peptidoglycan synthetase domain protein.
  
  
 0.421
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
   
 0.412
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.