STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (331 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.999
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: aoe:Clos_1330 glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III.
 
 0.998
Cthe_2528
KEGG: aoe:Clos_1328 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4.
 
  
 0.993
Cthe_2526
KEGG: aoe:Clos_1326 precorrin-6X reductase.
  
 0.988
Cthe_2529
Porphobilinogen synthase; KEGG: aoe:Clos_1329 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.969
Cthe_2531
KEGG: dhd:Dhaf_4118 sulfate ABC transporter, periplasmic sulfate-binding protein; TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein family 1.
     
 0.629
Cthe_2533
KEGG: dsy:DSY2956 hypothetical protein; TIGRFAM: sulfate ABC transporter, inner membrane subunit CysW; sulfate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component.
     
 0.624
Cthe_2536
PFAM: phosphoadenosine phosphosulfate reductase; KEGG: dsy:DSY2952 sulfate adenylyltransferase subunit 2.
     
 0.612
Cthe_2219
PFAM: flagellar protein FlaG protein; KEGG: cce:Ccel_0104 flagellar protein FlaG protein.
  
   0.604
ispH
Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
      
 0.559
Your Current Organism:
Hungateiclostridium thermocellum
NCBI taxonomy Id: 203119
Other names: Clostridium thermocellum ATCC 27405, H. thermocellum ATCC 27405, Hungateiclostridium thermocellum ATCC 27405, Ruminiclostridium thermocellum ATCC 27405
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