node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cthe_1499 | Cthe_1946 | Cthe_1499 | Cthe_1946 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Thioredoxin domain-containing protein; KEGG: chy:CHY_0560 thioredoxin/thioredoxin-disulfide reductase. | 0.857 |
Cthe_1499 | dapB | Cthe_1499 | Cthe_0963 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.472 |
Cthe_1499 | dapB-2 | Cthe_1499 | Cthe_1170 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.472 |
Cthe_1499 | dapF | Cthe_1499 | Cthe_3100 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.787 |
Cthe_1499 | dapL | Cthe_1499 | Cthe_3101 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. Can also use m-DAP instead of LL-DAP as the amino- group donor. | 0.818 |
Cthe_1499 | ddh | Cthe_1499 | Cthe_0922 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate (m-DAP), since the activity with L,L-2,6-diaminopimelate is less than 5% of the activity observed with m-DAP. Can use NAD(+) only very poorly since the activity observed in the presence of NAD(+) is about 0.3% of that with NADP(+). | 0.573 |
Cthe_1499 | lysA | Cthe_1499 | Cthe_0683 | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.839 |
Cthe_1946 | Cthe_1499 | Cthe_1946 | Cthe_1499 | PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Thioredoxin domain-containing protein; KEGG: chy:CHY_0560 thioredoxin/thioredoxin-disulfide reductase. | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.857 |
Cthe_1946 | dapL | Cthe_1946 | Cthe_3101 | PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Thioredoxin domain-containing protein; KEGG: chy:CHY_0560 thioredoxin/thioredoxin-disulfide reductase. | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. Can also use m-DAP instead of LL-DAP as the amino- group donor. | 0.693 |
Cthe_1946 | lysA | Cthe_1946 | Cthe_0683 | PFAM: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Thioredoxin domain-containing protein; KEGG: chy:CHY_0560 thioredoxin/thioredoxin-disulfide reductase. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.733 |
Cthe_3102 | dapF | Cthe_3102 | Cthe_3100 | KEGG: cpr:CPR_2090 transcription regulator LytR-like protein; TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.445 |
Cthe_3102 | dapL | Cthe_3102 | Cthe_3101 | KEGG: cpr:CPR_2090 transcription regulator LytR-like protein; TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator. | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. Can also use m-DAP instead of LL-DAP as the amino- group donor. | 0.701 |
dapB | Cthe_1499 | Cthe_0963 | Cthe_1499 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | KEGG: afw:Anae109_3636 ammonium transporter; TIGRFAM: ammonium transporter; PFAM: ammonium transporter; nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.472 |
dapB | dapB-2 | Cthe_0963 | Cthe_1170 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.921 |
dapB | dapF | Cthe_0963 | Cthe_3100 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.895 |
dapB | dapL | Cthe_0963 | Cthe_3101 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. Can also use m-DAP instead of LL-DAP as the amino- group donor. | 0.911 |
dapB | ddh | Cthe_0963 | Cthe_0922 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate (m-DAP), since the activity with L,L-2,6-diaminopimelate is less than 5% of the activity observed with m-DAP. Can use NAD(+) only very poorly since the activity observed in the presence of NAD(+) is about 0.3% of that with NADP(+). | 0.779 |
dapB | lysA | Cthe_0963 | Cthe_0683 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.956 |
dapB | murA | Cthe_0963 | Cthe_2328 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.552 |
dapB | murB | Cthe_0963 | Cthe_0112 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.582 |