node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sde_1012 | hisA | Sde_1012 | Sde_0489 | Histidinol phosphate aminotransferase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.899 |
Sde_1012 | hisB | Sde_1012 | Sde_0487 | Histidinol phosphate aminotransferase. | Methyl-accepting chemotaxis sensory transducer / imidazoleglycerol-phosphate dehydratase. | 0.998 |
Sde_1012 | hisD | Sde_1012 | Sde_3168 | Histidinol phosphate aminotransferase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
Sde_1012 | hisE | Sde_1012 | Sde_3223 | Histidinol phosphate aminotransferase. | phosphoribosyl-ATP pyrophosphatase. | 0.826 |
Sde_1012 | hisF | Sde_1012 | Sde_0490 | Histidinol phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.930 |
Sde_1012 | hisG | Sde_1012 | Sde_3169 | Histidinol phosphate aminotransferase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.935 |
Sde_1012 | hisH | Sde_1012 | Sde_0488 | Histidinol phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.958 |
Sde_1012 | hisI | Sde_1012 | Sde_3222 | Histidinol phosphate aminotransferase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.879 |
Sde_1012 | hisZ | Sde_1012 | Sde_2662 | Histidinol phosphate aminotransferase. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.774 |
Sde_2372 | hisA | Sde_2372 | Sde_0489 | L-threonine O-3-phosphate decarboxylase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.856 |
Sde_2372 | hisB | Sde_2372 | Sde_0487 | L-threonine O-3-phosphate decarboxylase. | Methyl-accepting chemotaxis sensory transducer / imidazoleglycerol-phosphate dehydratase. | 0.936 |
Sde_2372 | hisD | Sde_2372 | Sde_3168 | L-threonine O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.930 |
Sde_2372 | hisE | Sde_2372 | Sde_3223 | L-threonine O-3-phosphate decarboxylase. | phosphoribosyl-ATP pyrophosphatase. | 0.800 |
Sde_2372 | hisF | Sde_2372 | Sde_0490 | L-threonine O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.914 |
Sde_2372 | hisG | Sde_2372 | Sde_3169 | L-threonine O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.842 |
Sde_2372 | hisH | Sde_2372 | Sde_0488 | L-threonine O-3-phosphate decarboxylase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.926 |
Sde_2372 | hisI | Sde_2372 | Sde_3222 | L-threonine O-3-phosphate decarboxylase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.937 |
Sde_2372 | hisZ | Sde_2372 | Sde_2662 | L-threonine O-3-phosphate decarboxylase. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.774 |
hisA | Sde_1012 | Sde_0489 | Sde_1012 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol phosphate aminotransferase. | 0.899 |
hisA | Sde_2372 | Sde_0489 | Sde_2372 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | L-threonine O-3-phosphate decarboxylase. | 0.856 |