node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sde_0654 | Sde_2356 | Sde_0654 | Sde_2356 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.854 |
Sde_0654 | Sde_3666 | Sde_0654 | Sde_3666 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.857 |
Sde_0654 | cysG | Sde_0654 | Sde_1698 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.894 |
Sde_0654 | hemC | Sde_0654 | Sde_3667 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
Sde_0654 | hemE | Sde_0654 | Sde_2681 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.745 |
Sde_1669 | Sde_2013 | Sde_1669 | Sde_2013 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | 0.999 |
Sde_1669 | Sde_2356 | Sde_1669 | Sde_2356 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.822 |
Sde_1669 | cysC | Sde_1669 | Sde_2136 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.998 |
Sde_1669 | cysD | Sde_1669 | Sde_2145 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Sulfate adenylyltransferase subunit 2. | 0.995 |
Sde_1669 | cysG | Sde_1669 | Sde_1698 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.953 |
Sde_2013 | Sde_1669 | Sde_2013 | Sde_1669 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | 0.999 |
Sde_2013 | Sde_2356 | Sde_2013 | Sde_2356 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.872 |
Sde_2013 | cysC | Sde_2013 | Sde_2136 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.937 |
Sde_2013 | cysD | Sde_2013 | Sde_2145 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | Sulfate adenylyltransferase subunit 2. | 0.924 |
Sde_2013 | cysG | Sde_2013 | Sde_1698 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.986 |
Sde_2356 | Sde_0654 | Sde_2356 | Sde_0654 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.854 |
Sde_2356 | Sde_1669 | Sde_2356 | Sde_1669 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | 0.822 |
Sde_2356 | Sde_2013 | Sde_2356 | Sde_2013 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein. | 0.872 |
Sde_2356 | Sde_3665 | Sde_2356 | Sde_3665 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Protein of unknown function DUF513, hemX. | 0.902 |
Sde_2356 | Sde_3666 | Sde_2356 | Sde_3666 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.919 |