STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (142 aa)    
Predicted Functional Partners:
Tery_2084
PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: dsy:DSY4925 hypothetical protein.
  
 0.987
Tery_2082
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.958
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.946
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
 0.936
Tery_1774
5'-nucleotidase / 3'-nucleotidase / exopolyphosphatase; KEGG: ana:alr3139 putative acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE.
     
  0.900
Tery_2384
3'-nucleotidase / exopolyphosphatase / 5'-nucleotidase; KEGG: ana:alr3139 putative acid phosphatase; TIGRFAM: stationary-phase survival protein SurE; PFAM: Survival protein SurE.
     
  0.900
surE
5'-nucleotidase / 3'-nucleotidase / exopolyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
Tery_0008
PFAM: DNA polymerase III, beta chain; KEGG: ava:Ava_0002 DNA polymerase III subunit beta.
  
  
 0.885
Tery_2643
Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.883
Tery_1293
TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 pseudouridine synthase; KEGG: ana:all3873 putative pseudouridylate synthase; Belongs to the pseudouridine synthase RsuA family.
      0.752
Your Current Organism:
Trichodesmium erythraeum
NCBI taxonomy Id: 203124
Other names: T. erythraeum IMS101, Trichodesmium erythraeum IMS101, Trichodesmium erythraeum str. IMS101, Trichodesmium erythraeum strain IMS101, Trichodesmium sp. IMS101
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.