node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TWT_346 | TWT_349 | TWT_346 | TWT_349 | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Transcriptional regulator. | 0.675 |
TWT_346 | TWT_350 | TWT_346 | TWT_350 | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Unknown. | 0.510 |
TWT_346 | cysS1 | TWT_346 | TWT_347 | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.928 |
TWT_346 | ispDF | TWT_346 | TWT_348 | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | IspD; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.700 |
TWT_349 | TWT_346 | TWT_349 | TWT_346 | Transcriptional regulator. | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.675 |
TWT_349 | TWT_350 | TWT_349 | TWT_350 | Transcriptional regulator. | Unknown. | 0.672 |
TWT_349 | cysS1 | TWT_349 | TWT_347 | Transcriptional regulator. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.675 |
TWT_349 | ispDF | TWT_349 | TWT_348 | Transcriptional regulator. | IspD; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.894 |
TWT_350 | TWT_346 | TWT_350 | TWT_346 | Unknown. | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.510 |
TWT_350 | TWT_349 | TWT_350 | TWT_349 | Unknown. | Transcriptional regulator. | 0.672 |
TWT_350 | cysS1 | TWT_350 | TWT_347 | Unknown. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.513 |
TWT_350 | ispDF | TWT_350 | TWT_348 | Unknown. | IspD; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.693 |
cysS1 | TWT_346 | TWT_347 | TWT_346 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | tRNA/rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.928 |
cysS1 | TWT_349 | TWT_347 | TWT_349 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Transcriptional regulator. | 0.675 |
cysS1 | TWT_350 | TWT_347 | TWT_350 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Unknown. | 0.513 |
cysS1 | ispDF | TWT_347 | TWT_348 | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | IspD; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.675 |
dxr | folPXK | TWT_089 | TWT_586 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 7,8-dihydroneopterin aldolase/epimerase/oxygenase; DHPS/FolB/HPPK; implicated resistence to sulfonamide. | 0.446 |
dxr | ispDF | TWT_089 | TWT_348 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | IspD; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.984 |
dxr | ispE | TWT_089 | TWT_605 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.842 |
dxr | ispG | TWT_089 | TWT_186 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.848 |