node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TWT_731 | TWT_734 | TWT_731 | TWT_734 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unknown. | 0.829 |
TWT_731 | hemA | TWT_731 | TWT_736 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase (GLUTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.743 |
TWT_731 | hemB | TWT_731 | TWT_730 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.952 |
TWT_731 | hemC | TWT_731 | TWT_732 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
TWT_731 | hemE | TWT_731 | TWT_735 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.971 |
TWT_731 | hemL | TWT_731 | TWT_729 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.882 |
TWT_731 | hemZ | TWT_731 | TWT_733 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.879 |
TWT_734 | TWT_731 | TWT_734 | TWT_731 | Unknown. | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.829 |
TWT_734 | hemA | TWT_734 | TWT_736 | Unknown. | glutamyl-tRNA reductase (GLUTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.562 |
TWT_734 | hemB | TWT_734 | TWT_730 | Unknown. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.829 |
TWT_734 | hemC | TWT_734 | TWT_732 | Unknown. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.835 |
TWT_734 | hemE | TWT_734 | TWT_735 | Unknown. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.668 |
TWT_734 | hemL | TWT_734 | TWT_729 | Unknown. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.832 |
TWT_734 | hemZ | TWT_734 | TWT_733 | Unknown. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.991 |
cycY | hemA | TWT_756 | TWT_736 | Thiol:disulfide interchange protein. | glutamyl-tRNA reductase (GLUTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.715 |
cycY | hemE | TWT_756 | TWT_735 | Thiol:disulfide interchange protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.738 |
cycY | hemL | TWT_756 | TWT_729 | Thiol:disulfide interchange protein. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.880 |
gltS | hemA | TWT_209 | TWT_736 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | glutamyl-tRNA reductase (GLUTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.970 |
gltS | hemB | TWT_209 | TWT_730 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.470 |
gltS | hemL | TWT_209 | TWT_729 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.723 |