node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | folA | Bfl184 | Bfl124 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | 0.726 |
birA | folB | Bfl184 | Bfl061 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.745 |
birA | folC | Bfl184 | Bfl494 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.583 |
birA | folE | Bfl184 | Bfl472 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | GTP cyclohydrolase I; COG category=H. | 0.637 |
birA | folK | Bfl184 | Bfl150 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG category=H. | 0.692 |
birA | folP | Bfl184 | Bfl099 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.723 |
birA | ndk | Bfl184 | Bfl533 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | Pseudogene of GcpE protein (protein E); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.524 |
birA | ribA | Bfl184 | Bfl425 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. | 0.623 |
folA | birA | Bfl124 | Bfl184 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | 0.726 |
folA | folB | Bfl124 | Bfl061 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.723 |
folA | folC | Bfl124 | Bfl494 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.960 |
folA | folE | Bfl124 | Bfl472 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | GTP cyclohydrolase I; COG category=H. | 0.820 |
folA | folK | Bfl124 | Bfl150 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG category=H. | 0.709 |
folA | folP | Bfl124 | Bfl099 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.840 |
folA | ribA | Bfl124 | Bfl425 | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. | 0.409 |
folB | birA | Bfl061 | Bfl184 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; COG category=K. | 0.745 |
folB | folA | Bfl061 | Bfl124 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase type I; COG category=H; Belongs to the dihydrofolate reductase family. | 0.723 |
folB | folC | Bfl061 | Bfl494 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.906 |
folB | folE | Bfl061 | Bfl472 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I; COG category=H. | 0.959 |
folB | folK | Bfl061 | Bfl150 | Dihydroneopterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG category=H. | 0.997 |