node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dapF | ribD | Bfl579 | Bfl234 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.563 |
dapF | yigB | Bfl579 | Bfl578 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.741 |
degQ | yigB | Bfl047 | Bfl578 | Serine protease; COG category=O; Belongs to the peptidase S1C family. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.518 |
ftsL | ftsQ | Bfl135 | Bfl144 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.995 |
ftsL | tolA | Bfl135 | Bfl337 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | tolA protein; COG category=N. | 0.769 |
ftsL | yigB | Bfl135 | Bfl578 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.628 |
ftsL | ytfN | Bfl135 | Bfl090 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Pseudogene of YtfM, putative exported protein; COG category=M. | 0.628 |
ftsQ | ftsL | Bfl144 | Bfl135 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.995 |
ftsQ | tolA | Bfl144 | Bfl337 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | tolA protein; COG category=N. | 0.423 |
ftsQ | yigB | Bfl144 | Bfl578 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.522 |
ribD | dapF | Bfl234 | Bfl579 | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.563 |
ribD | ribE | Bfl234 | Bfl366 | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin synthase alpha chain; COG category=H. | 0.999 |
ribD | ribF | Bfl234 | Bfl117 | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin biosynthesis protein RibF; COG category=H; Belongs to the ribF family. | 0.678 |
ribD | ribH | Bfl234 | Bfl235 | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase beta chain); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.998 |
ribD | yigB | Bfl234 | Bfl578 | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.965 |
ribE | ribD | Bfl366 | Bfl234 | Riboflavin synthase alpha chain; COG category=H. | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
ribE | ribF | Bfl366 | Bfl117 | Riboflavin synthase alpha chain; COG category=H. | Riboflavin biosynthesis protein RibF; COG category=H; Belongs to the ribF family. | 0.934 |
ribE | ribH | Bfl366 | Bfl235 | Riboflavin synthase alpha chain; COG category=H. | 6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase beta chain); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.998 |
ribE | yigB | Bfl366 | Bfl578 | Riboflavin synthase alpha chain; COG category=H. | Predicted hydrolase of the HAD superfamily; COG category=R. | 0.901 |
ribF | ribD | Bfl117 | Bfl234 | Riboflavin biosynthesis protein RibF; COG category=H; Belongs to the ribF family. | Bifunctional pyrimidine deaminase/reductase in pathway of riboflavin synthesis; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.678 |