node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR0409 | HEAR1764 | HEAR0409 | HEAR1764 | Conserved hypothetical protein, putative ATPase; Homologs of previously reported genes of unknown function. | Putative Peptidase M22, glycoprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.980 |
HEAR0409 | HEAR2179 | HEAR0409 | HEAR2179 | Conserved hypothetical protein, putative ATPase; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | 0.600 |
HEAR0409 | tsaD | HEAR0409 | HEAR0426 | Conserved hypothetical protein, putative ATPase; Homologs of previously reported genes of unknown function. | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.913 |
HEAR1764 | HEAR0409 | HEAR1764 | HEAR0409 | Putative Peptidase M22, glycoprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein, putative ATPase; Homologs of previously reported genes of unknown function. | 0.980 |
HEAR1764 | HEAR2179 | HEAR1764 | HEAR2179 | Putative Peptidase M22, glycoprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | 0.600 |
HEAR1764 | tsaD | HEAR1764 | HEAR0426 | Putative Peptidase M22, glycoprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.954 |
HEAR2179 | HEAR0409 | HEAR2179 | HEAR0409 | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | Conserved hypothetical protein, putative ATPase; Homologs of previously reported genes of unknown function. | 0.600 |
HEAR2179 | HEAR1764 | HEAR2179 | HEAR1764 | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | Putative Peptidase M22, glycoprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.600 |
HEAR2179 | ksgA | HEAR2179 | HEAR0369 | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.426 |
HEAR2179 | tsaD | HEAR2179 | HEAR0426 | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.624 |
ksgA | HEAR2179 | HEAR0369 | HEAR2179 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Conserved hypothetical protein, putative translation factor; Homologs of previously reported genes of unknown function; Belongs to the SUA5 family. | 0.426 |
ksgA | lepA | HEAR0369 | HEAR2066 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.482 |
ksgA | leuS | HEAR0369 | HEAR2661 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Leucyl-tRNA synthetase (Leucine--tRNA ligase) (LeuRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.503 |
ksgA | lolD | HEAR0369 | HEAR2223 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Lipoprotein releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. | 0.653 |
ksgA | pheS | HEAR0369 | HEAR1797 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Phenylalanyl-tRNA synthetase alpha chain (Phenylalanine--tRNA ligase alpha chain) (PheRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.528 |
ksgA | tsaD | HEAR0369 | HEAR0426 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.755 |
ksgA | tufA | HEAR0369 | HEAR3169 | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.582 |
lepA | ksgA | HEAR2066 | HEAR0369 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.482 |
lepA | leuS | HEAR2066 | HEAR2661 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Leucyl-tRNA synthetase (Leucine--tRNA ligase) (LeuRS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.573 |
lepA | map | HEAR2066 | HEAR1334 | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Methionine aminopeptidase (MAP) (Peptidase M); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.546 |