node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR0281 | HEAR0968 | HEAR0281 | HEAR0968 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.914 |
HEAR0281 | cbiA | HEAR0281 | HEAR0965 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.920 |
HEAR0281 | cobD | HEAR0281 | HEAR0628 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative cobalamin biosynthesis protein CobD-like; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.925 |
HEAR0281 | cobD-2 | HEAR0281 | HEAR0967 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.920 |
HEAR0281 | cobO | HEAR0281 | HEAR0964 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.942 |
HEAR0281 | cobQ | HEAR0281 | HEAR0970 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.923 |
HEAR0281 | cobS | HEAR0281 | HEAR0955 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Putative cobalamin synthase cobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.927 |
HEAR0281 | cobU | HEAR0281 | HEAR0966 | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | Bifunctional adenosylcobalamin biosynthesis protein cobU [Includes: Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.927 |
HEAR0968 | HEAR0281 | HEAR0968 | HEAR0281 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.914 |
HEAR0968 | cbiA | HEAR0968 | HEAR0965 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.911 |
HEAR0968 | cobD | HEAR0968 | HEAR0628 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative cobalamin biosynthesis protein CobD-like; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.942 |
HEAR0968 | cobD-2 | HEAR0968 | HEAR0967 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.995 |
HEAR0968 | cobO | HEAR0968 | HEAR0964 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Corrinoid adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.987 |
HEAR0968 | cobQ | HEAR0968 | HEAR0970 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.998 |
HEAR0968 | cobS | HEAR0968 | HEAR0955 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative cobalamin synthase cobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.640 |
HEAR0968 | cobT | HEAR0968 | HEAR0954 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.758 |
HEAR0968 | cobU | HEAR0968 | HEAR0966 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional adenosylcobalamin biosynthesis protein cobU [Includes: Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.993 |
cbiA | HEAR0281 | HEAR0965 | HEAR0281 | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.920 |
cbiA | HEAR0968 | HEAR0965 | HEAR0968 | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.911 |
cbiA | cobD | HEAR0965 | HEAR0628 | Putative Cobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative cobalamin biosynthesis protein CobD-like; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.550 |