node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR0194 | ubiA | HEAR0194 | HEAR0299 | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.608 |
HEAR0194 | ubiD | HEAR0194 | HEAR1041 | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.911 |
HEAR0194 | ubiX | HEAR0194 | HEAR3020 | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.911 |
HEAR0755 | ubiD | HEAR0755 | HEAR1041 | Putative Ferredoxin--NAD(+) reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.653 |
ubiA | HEAR0194 | HEAR0299 | HEAR0194 | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.608 |
ubiA | ubiD | HEAR0299 | HEAR1041 | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.961 |
ubiA | ubiE | HEAR0299 | HEAR2856 | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.463 |
ubiA | ubiX | HEAR0299 | HEAR3020 | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.950 |
ubiD | HEAR0194 | HEAR1041 | HEAR0194 | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.911 |
ubiD | HEAR0755 | HEAR1041 | HEAR0755 | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Putative Ferredoxin--NAD(+) reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.653 |
ubiD | ubiA | HEAR1041 | HEAR0299 | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.961 |
ubiD | ubiE | HEAR1041 | HEAR2856 | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.547 |
ubiD | ubiX | HEAR1041 | HEAR3020 | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.995 |
ubiE | ubiA | HEAR2856 | HEAR0299 | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.463 |
ubiE | ubiD | HEAR2856 | HEAR1041 | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.547 |
ubiX | HEAR0194 | HEAR3020 | HEAR0194 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | Putative Ubiquinone biosynthesis hydroxylase VisC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.911 |
ubiX | ubiA | HEAR3020 | HEAR0299 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.950 |
ubiX | ubiD | HEAR3020 | HEAR1041 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 3-octaprenyl-4-hydroxybenzoate decarboxylase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.995 |