node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR2221 | bamE | HEAR2221 | HEAR2656 | Hypothetical protein; No homology to any previously reported sequences. | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.421 |
HEAR2221 | holA | HEAR2221 | HEAR2663 | Hypothetical protein; No homology to any previously reported sequences. | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | 0.800 |
HEAR2221 | recA | HEAR2221 | HEAR2628 | Hypothetical protein; No homology to any previously reported sequences. | Protein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.544 |
HEAR2221 | recX | HEAR2221 | HEAR2627 | Hypothetical protein; No homology to any previously reported sequences. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.746 |
bamE | HEAR2221 | HEAR2656 | HEAR2221 | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Hypothetical protein; No homology to any previously reported sequences. | 0.421 |
bamE | holA | HEAR2656 | HEAR2663 | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | 0.772 |
bamE | recO | HEAR2656 | HEAR2061 | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | DNA repair protein recO (Recombination protein O); Involved in DNA repair and RecF pathway recombination. | 0.548 |
bamE | recX | HEAR2656 | HEAR2627 | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.635 |
dinB | lexA | HEAR3363 | HEAR2163 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.969 |
dinB | recA | HEAR3363 | HEAR2628 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Protein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.941 |
dinB | recX | HEAR3363 | HEAR2627 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.809 |
holA | HEAR2221 | HEAR2663 | HEAR2221 | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | Hypothetical protein; No homology to any previously reported sequences. | 0.800 |
holA | bamE | HEAR2663 | HEAR2656 | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | Hypothetical protein, putative SmpA/OmlA domain; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.772 |
holA | recO | HEAR2663 | HEAR2061 | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | DNA repair protein recO (Recombination protein O); Involved in DNA repair and RecF pathway recombination. | 0.508 |
holA | recX | HEAR2663 | HEAR2627 | DNA polymerase III, delta subunit; Function of strongly homologous gene; enzyme. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.707 |
lexA | dinB | HEAR2163 | HEAR3363 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.969 |
lexA | recA | HEAR2163 | HEAR2628 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Protein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.991 |
lexA | recX | HEAR2163 | HEAR2627 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.845 |
lexA | sodB | HEAR2163 | HEAR2498 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.685 |
radA | recA | HEAR1758 | HEAR2628 | DNA repair protein RadA (DNA repair protein Sms); DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | Protein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.964 |