node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HEAR1380 | folE | HEAR1380 | HEAR1481 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | 0.985 |
HEAR1380 | queA | HEAR1380 | HEAR0303 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.405 |
HEAR1380 | queC | HEAR1380 | HEAR2938 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.940 |
HEAR1380 | queE | HEAR1380 | HEAR1379 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.997 |
HEAR1380 | queF | HEAR1380 | HEAR2862 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | NADPH-dependent 7-cyano-7-deazaguanine reductase (NADPH-dependent nitrile oxidoreductase); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.862 |
HEAR1380 | tgt | HEAR1380 | HEAR0304 | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowin [...] | 0.467 |
HEAR1867 | queC | HEAR1867 | HEAR2938 | Putative flagellar protein FlaG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.572 |
HEAR2936 | HEAR2937 | HEAR2936 | HEAR2937 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.710 |
HEAR2936 | queC | HEAR2936 | HEAR2938 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.487 |
HEAR2937 | HEAR2936 | HEAR2937 | HEAR2936 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.710 |
HEAR2937 | queC | HEAR2937 | HEAR2938 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.612 |
folE | HEAR1380 | HEAR1481 | HEAR1380 | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.985 |
folE | queA | HEAR1481 | HEAR0303 | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.415 |
folE | queC | HEAR1481 | HEAR2938 | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.467 |
folE | queE | HEAR1481 | HEAR1379 | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.608 |
folE | queF | HEAR1481 | HEAR2862 | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | NADPH-dependent 7-cyano-7-deazaguanine reductase (NADPH-dependent nitrile oxidoreductase); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.500 |
queA | HEAR1380 | HEAR0303 | HEAR1380 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.405 |
queA | folE | HEAR0303 | HEAR1481 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | GTP cyclohydrolase I (GTP-CH-I); Function of strongly homologous gene; enzyme. | 0.415 |
queA | queC | HEAR0303 | HEAR2938 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.518 |
queA | queE | HEAR0303 | HEAR1379 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein QueA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.465 |