node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MetH | Psyr_0607 | Psyr_2464 | Psyr_0607 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.975 |
MetH | Psyr_1583 | Psyr_2464 | Psyr_1583 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.890 |
MetH | Psyr_2855 | Psyr_2464 | Psyr_2855 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent). | 0.973 |
MetH | Psyr_3916 | Psyr_2464 | Psyr_3916 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.973 |
MetH | ahcY | Psyr_2464 | Psyr_0460 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.959 |
MetH | ilvA | Psyr_2464 | Psyr_1672 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.898 |
MetH | metZ | Psyr_2464 | Psyr_1669 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.975 |
Psyr_0607 | MetH | Psyr_0607 | Psyr_2464 | Cystathionine beta-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.975 |
Psyr_0607 | Psyr_1583 | Psyr_0607 | Psyr_1583 | Cystathionine beta-lyase. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.973 |
Psyr_0607 | Psyr_2855 | Psyr_0607 | Psyr_2855 | Cystathionine beta-lyase. | Methionine synthase (B12-independent). | 0.944 |
Psyr_0607 | Psyr_3916 | Psyr_0607 | Psyr_3916 | Cystathionine beta-lyase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.944 |
Psyr_0607 | ahcY | Psyr_0607 | Psyr_0460 | Cystathionine beta-lyase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.923 |
Psyr_0607 | ilvA | Psyr_0607 | Psyr_1672 | Cystathionine beta-lyase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.830 |
Psyr_0607 | metZ | Psyr_0607 | Psyr_1669 | Cystathionine beta-lyase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.923 |
Psyr_1433 | Psyr_2828 | Psyr_1433 | Psyr_2828 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | C-5 cytosine-specific DNA methylase. | 0.900 |
Psyr_1433 | Psyr_2843 | Psyr_1433 | Psyr_2843 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | C-5 cytosine-specific DNA methylase. | 0.900 |
Psyr_1433 | ahcY | Psyr_1433 | Psyr_0460 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.904 |
Psyr_1583 | MetH | Psyr_1583 | Psyr_2464 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.890 |
Psyr_1583 | Psyr_0607 | Psyr_1583 | Psyr_0607 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine beta-lyase. | 0.973 |
Psyr_1583 | Psyr_2855 | Psyr_1583 | Psyr_2855 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase (B12-independent). | 0.817 |