STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folDBifunctional methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase; Formyltetrahydrofolate synthetase; Fhs; FthFS; Fhs; COG family: formyltetrahydrofolate synthetase; PFAM_ID: FTHFS; Belongs to the formate--tetrahydrofolate ligase family.
 
 
 0.993
glyA
GlyA; COG family: glycine hydroxymethyltransferase; PFAM_ID: SHMT; PFAM_ID: SHMT.
 
 0.989
purH
PurH; IMP synthetase; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in aful); PFAM_ID: MGS; PFAM_ID: AICARFT_IMPCHas.
 
 
 0.967
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.953
metF
MetF; COG family: 5,10-methylenetetrahydrofolate reductase; PFAM_ID: MTHFR; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.928
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.925
purT
Probable phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
     
 0.904
purL
PurL.
  
  
 0.798
purB
Adenylosuccinate lyase; Adenylosuccinase; PurB; COG family: adenylosuccinate lyase; PFAM_ID: lyase_1.
  
  
 0.772
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.708
Your Current Organism:
Bifidobacterium longum
NCBI taxonomy Id: 206672
Other names: B. longum NCC2705, Bifidobacterium longum NCC2705, Bifidobacterium longum str. NCC2705
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.